After I got linked to it via reddit, I was hoping against hope that this was some sort of hoax, a commentary, perhaps, on the degraded, increasingly inane state of mass media entertainment.

No, it's real. IMDB confirms that it will include the voices of Drew Barrymore, Salma Hayek, and Jamie Lee Curtis, all of whom will presumably, some might say hopefully, fall victim to some ancient Aztec curse shortly thereafter. (Or is it Incan? Some reddit commenters have pointed out that the trailer seems rather vague on the matter.)

Late edit: I only just now noticed this, but the rapping chihuahua (two words that should never appear consecutively, by the way), who is ostensibly Aztec (Incan? Mexican? You know, one of those Spanish countries down thurrr), has what is more or less a Brooklyn accent. Sweet.